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5 in Lancet Oncology , the IOTA studys interim analysis found that women who were managed conservatively had a low risk for subsequent malignancy or severe complications requiring surgery to remove the cyst or entire ovary

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Brambilla D, Franciosi S, Opp MR, Imeri L (2007) Interleukin-1 inhibits firing of serotonergic neurons in the dorsal raphe nucleus and enhances gabaergic inhibitory post-synaptic potentials